Eugene DeSombre, Ph.D.
Appointments:

Professor Emeritus, Ben May Department for Cancer Research

Committee on Cancer Biology

The Cancer Research Center

 

Education:

Ph.D. University of Chicago, 1963

Contact:

CIS W332

Voice: 773/ 702.6995
Fax: 773/ 702.6260

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Eugene R. DeSombre, Ph.D.
Research / References


DeSombre ER, Shafii B, Hanson N, Kuivanen PC, Hughes A (1992) Estrogen receptor-directed radiotoxicity with Auger electrons: specificity and mean lethal dose. Cancer Res 52:5752-5758.

DeSombre ER (1993) The biology of estrogen and progestin receptors. In: Current Therapy in Oncology (Neiderhuber JE, ed). B.C. Decker, Inc., Philadelphia, pp 336-343.

Puy LA, Kuivanen PC, DeSombre ER (1993) Immunohistochemical localization of the estrogen-responsive 110k and 74k proteins and complement component C3 in the rat genital tract after estrogen treatment and during the estrous cycle. J Reprod Fertil 99:385-394 (1994).

DeSombre ER, Pribish J, Hughes A (1995) Comparison of the distribution of radioiodinated di- and tri-hydroxyphenlethylene estrogens in the immature female rat. Nucl. Med. Biol. 22:679-687.

Schwartz JL, Mustafi R, Hughes A, DeSombre, ER (1996) DNA and chromosome breaks induced by iodine-123-labeled estrogen in Chinese hamster ovary cells. Radiat. Res. 146:151-158.

Kearney T, Hughes A, Hanson RN and DeSombre ER (1999) Radiotoxicity of Auger electron-emitting estrogens for MCF-7 spheroids: A potential treatment for estrogen receptor-positive tumors. Rad. Res. 151: 570-579

DeSombre ER and Jensen EV (2000) Steroid Hormone Binding and Hormone Receptors, In: Cancer Medicine, pp 706-714, 5th Edition, J. F. Holland, E. Frei, III, R. C. Bast, Jr., D. W. Kufe, R. E. Pollock and R. R. Weichselbaum, Editors, B. C. Decker, Hamilton, Ont.

Hanson, RN, Lee, CY, Friel, C, Dilis, R, Hughes, A, and DeSombre, ER. (2003) Evaluation of 17α-E(Trifluoromethylphenyl)vinyl Estradiols as Novel Estrogen Receptor Ligands. Steroids 68:143-148.

Hanson, RN, Friel, CL, Dilis, R, Hughes, A, and DeSombre, ER. (2005) Synthesis and Evaluation of (17α-20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diol as Ligands for the Estrogen Receptor-alpha Hormone Binding Domain: Comparison with 20E-isomers. J. Med. Chem. 48:4300-4311.