
Associate Professor, Ben May Department for Cancer Research
Committee on Developmental Biology
Committee on Genetics
Committee on Cancer Biology
The Cancer Research Center
Ph.D. Harvard University, 1994
Contact:
Knapp Room R314
Voice: 773/ 834.1949
Fax: 773/ 702.4394
Wei Du , Ph.D.
Research / References
Pogoriler J., Millen, K., Utset, M., and Du, W. (2006) Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation. Development, Aug 30; [Epub ahead of print].
Shafaee, Z., Schmidt, H., Du, W., Posner, M., Weichselbaum, R., (2006) Cyclopamine increases the cytotoxic effects of taxol and radiation in Hedgehog expressing pancreatic cancer. Cancer Chemother Pharmacol. Mar 22; [Epub ahead of print]
Du, W. and Pogoriler, J (2006) Retinoblastoma Family Genes. Oncogene, 25, 5190-5200.
Lee, S., Zhang, X., Zhou, G., Shapino, J., Bao, J., Xu, J., Sun, M., Shi, R., Chen, J., Clark, T., Johnson, D., Tseng, C., Yang, H., Du, W., Wu, C., Wang, J., and Wang, S. (2005) Detecting novel low-abundant transcripts in Drosophila. RNA, 11, 939–946.
Duman-Scheel, M., Johnston, L., and Du, W. (2004) Repression of dMyc expression by Wingless promotes RBF-induced G1 arrest in the Presumptive Drosophila Wing Margin. PNAS, 101, 3857–3862.
Pogoriler, J and Du, W. (2004) Chk1 activation and the nuclear/cytoplasmic ratio. Developmental Cell, 7, 147-148.
Weng, L., Zhu, C., Xu, J. and Du, W. (2003) Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J., 22, 3865-3875.
Du, W. (2003) Endocycle and E2F-dependent transcriptional activation and repression. Cell Cycle, 2, 515-516.
Duman-Scheel, M., Weng, L., Xin, S., and Du, W. (2002) Hedgehog signaling controls cell proliferation and growth through upregulation of Cyclin D and Cyclin E. Nature, 417, 299-304.
Xin, S., Weng, L., Xu, J., and Du, W. (2002) The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 129, 1345-1356.
Xu, J., S. Xin, and W. Du. (2001). Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis. FEBS Letters 508, 394-398.
Bosco G., Du, W., Orr-Weaver, T. (2001) DNA replication control through interaction of E2FRB and the origin recognition complex. Nature Cell Biology, 3, 289-295.
Du, W. (2000) Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development. 127, 367-379.
Meyer, C.A., Jacobs, H.W., Datar, S.A., Du, W., Edgar, B.A., Christian F. Lehner, C.F. (2000) Drosophila Cdk4 stimulates growth and is dispensable for cell cycle progression. EMBO J. 19, 4533-4542.
Du, W., and Dyson, N. (1999) The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 18, 916-925.
Du, W., Vidal, M., Xie, J., and Dyson, N. (1996) RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes & Dev. 10, 1206-1218
Du, W., Xie, J., and Dyson, N. (1996) Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 15, 3684-3692.
Du, W. and Maniatis, T. (1994) The high Mobility group protein HMG I(Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms. Proc. Natl. Acad. Sci. USA 91. 11318-11322
Du, W., Thanos, D., and Maniatis, T. (1993) Mechanisms of Transcriptional Synergism between Distinct Virus Inducible Enhancer Elements. Cell 74, 887-898.
Du, W. and Maniatis, T. (1992) An ATF/CREB binding site is required for virus induction of the human interferon ß gene. Proc. Natl. Acad. Sci. USA 89. 2150-2154.
Maniatis, T., Whittemore, L. A., Du, W., Fan, C. M., Keller, A., Palombella, V. and Thanos, D. (1992) Positive and negative control of human interferon-ß gene expression. in Transcription Regulation, edited by McKnight, S. & Yamamoto, K., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 1193-1220.
