Ronald Harvey, Ph.D.
Appointments:

Professor Emeritus,
Ben May Department for Cancer Research

The Cancer Research Center

Education:

Ph.D. University of Chicago, 1960

Contact:

CIS W308

Voice: 773/ 702.6998
Fax: 773/ 702.6260

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Ronald G. Harvey, Ph.D.
Research / References


References

Ran C, Dai Q, Penning TM, Blair IA, and Harvey RG (2008) Strategies for synthesis of adducts of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. J. Org. Chem. 72: 992-1003.

Xu D, Duan Y, Blair IA, Penning TM, and Harvey RG (2008) Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labelled analogues. Org. Lett. 10: 1059-1062.

Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, and Penning TM (2007) Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry. Chem. Res. Tox. 20: 1331-1341.

Dai Q, Lim K, Xu D, and Harvey RG (2007) Efficient syntheses of C8-aryl adducts of adenine and guanine formed by reaction of radical-cation metabolites of carcinogenic polycyclic aromatic hydrocarbons with DNA. J. Org. Chem. 72: 4856-4863.

Ruan Q, Gelhaus SL, Penning TM, Harvey RG, and Blair IA (2007) Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells. Chem. Res. Toxicol. 20: 424-431.

Ruan Q, Kim HH, Jiang H, Penning TM, Harvey R., Blair IA (2006) Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 20: 1369-1380.

Park J-H, Troxel AB, Harvey RG, and Penning TM (2006) Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species. Chem. Res. Toxicol. 19: 719-728.

Dai Q, Ran C, and Harvey RG (2005) Synthesis of adducts of o-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. Organic Letters, 5, 999-1002.

Books

Harvey RG (1997) Polycyclic Aromatic Hydrocarbons. Wiley-VCH, New York (667 pages).

Harvey RG (1991) Polycyclic Aromatic Hydrocarbons: Chemistry and Carcinogenesis. Cambridge University Press, Cambridge, England.