
Professor,
Ben May Department for Cancer Research
Committee on Cancer Biology
Cancer Research Center
Ph.D. University of Alabama Birmingham, 1990
CIS W430
Voice: 773/ 753.1408
Fax: 773/ 702.6260
Anning Lin, Ph.D.
Research / References
Lin A. A Five-Year Itch in TNF Cytotoxicity: The Time Factor Determines JNK Action. Development Cell March 2006.
Liu J, Yang D, Minemoto Y, Leitges M, Rosner M.R, and Lin A*. NF-kB via PKCdelta Promotes JNK Activation by UV. Molecular Cell21:467-480, 2006.
Zhang J, Bui T, Xiang J, and Lin A*. cAMP Inhibits p38 Activation via CREB-induced Dynein Light Chain. Molecular and Cellular Biology 26:1223-1234,2006.
Zhang J, Liu J, Yu C, and Lin A*. Phosphorylation of the proapoptotic Bcl-2 family protein BAD at Ser128 inhibits BAD proapoptotic activity. Cancer Research 65:8372-8378. 2005.
Liu J, and Lin A*. Role of JNK activation in apoptosis: A double-edged sword. Cell Research 15:36-42, 2005.
Liu J, Minemoto Y, and Lin A*. JNK1, but not JNK2, is essential for TNF-induced c-Jun kinase activation and apoptosis. Molecular and Cellular Biology 24:10844-10856, 2004.
Yu C, Minemoto Y, Zhang J, Liu J, Tang F, Bui TN, Xiang J*, and Lin A*. JNK suppresses apoptosis via phosphorylation of the pro-apoptotic Bcl-2 family member BAD. Molecular Cell 13:32-9340, 2004.
Lin A. Integration of TNF signaling: crosstalk between IKK, JNK and caspases. In Yufan Shi et al., eds., Molecular Mechanisms of Programmed Cell Death. New York: Kluwer Academic/Plenum Pubishers, 213-210, 2003.
Lin A. Activation of the JNK signaling pathway: Breaking the Brake of Apoptosis. BioEssays 25:17-24, 2003.
Lin A* and Karin M. NF-kB in cancer: A marked target. Seminars in Cancer Biology 13:107-114, 2003.
Tang F, Tang G, Xiang J, Dai Q, Rosner MR, and Lin A*. Absence of NF-kB-mediated inhibition of JNK activation contributes to TNF-? induced apoptosis in MCF-7 cells. Molecular and Cellular Biology. 22:8571-8579, 2002.
Lin A* and Dibling B. The true face of JNK activation in apoptosis. Aging Cell 1:112-116, 2002.
Karin M and Lin A. NF-kB at the crossroad of life and death. Nature Immunology 3:221-227, 2002. (One of the most cited papers in the field, ISI, February 1st issue, 2003)
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, and Lin A*. Inhibition of JNK activation by NF-kB target genes. Nature 414:313-317, 2001. (News and Views, 414:265-266, 2001; Hot paper, The Scientist, 12:32-33, 2003)
Tang G, Yang J, Minemoto Y, and Lin A*. Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-induced apoptosis. Molecular Cell 8:1005-1016, 2001.
Purcell NH, Tang G, Yu C, Mercurio F, DiDonato JA, and Lin A*. Activation of NF-kB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes. Proceedings of National Academy of Science USA 98:6668-6673, 2001.
Zheng C, Xiang J, Hunter T, and Lin A*. Generation of a constitutively active c-Jun N-terminal protein kinase that stimulates c-Jun transcription activity. Journal of Biological Chemistry 274:28966-28971, 1999.
Nemoto S, DiDonato J A, and Lin A*. Coordinate regulation of IkB kinase by MEKK1 and NIK. Molecular and Cellular Biology 18:7336-7343, 1998.
Lu X, Nemoto S, Lin A*. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. Journal of Biological Chemistry (Communication) 272 :24751-24754, 1997.
Minden A, Lin A, Claret FX, Abo A, and Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cde42Hs. Cell 81:1147-1157, 1995.
tick Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, and Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290, 1995.
Minden A, Lin A, McMahon M, Lange-Carter, C, Derifard B, Davis R, Johnson G, and Karin M. Bifurcation in Ras signaling: Raf-1 and MEKK-1 differentially activate ERK and JNK MAP kinases. Science 256:1719-1723, 1994.
Hibi M, Lin A, Smeal T, Minden A, and Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Gen. & Dev. 7:2135-2148, 1993.
tick Lin A, Frost J, Deng T, Smeal T, Al-Alawi N, Kikkawa U, Hunter T, Brenner A, and Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70:777-789, 1992
