Assistant Professor,
Ben May Department for Cancer Research
Committee on Cancer Biology
Committee on Developmental Biology
Cancer Research Center
Committee on Immunology
B.Sc. University of Edinburgh, Scotland
Ph.D. The Beatson Institute for Cancer Research, University of Glasgow, Scotland
CIS W338
Voice: 773/ 834.1071
Fax: 773/ 702.3701
Kay Macleod , Ph.D.
Research / References
Kristin Tracy, Benjamin C. Dibling, Benjamin T. Spike, James Knabb, Paul Schumacker & Macleod KF: BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol. Cell Biol. 27, 6229-42 (2007).
Alexandra Dirlam, Benjamin Spike & Kay Macleod: De-regulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts" Molecular & Cellular Biology 27, 8713-28 (2007).
Spike, BT, Dibling BC & Macleod, KF: Hypoxic stress underlies defects in erythroblast islands in the Rb null mouse. Blood 110, 2173-81 (2007).
Abhinav Diwan, Andrew G Koesters, Amy M Odley, Suvarnamala Pushkaran, Christopher P Baines, Benjamin T Spike, Diedre Daria, Anil G Jegga, Hartmut Geiger, Bruce J Aronow, Jeffrey D Molkentin, Kay F Macleod, Theodosia A Kalfa, Gerald W Dorn II: Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc.Natl.Acad.Sci. USA 104, 6794-9 (2007).
Benjamin T Spike & Kay F. Macleod: Effects of hypoxia on heterotypic interactions with macrophages. Cell Cycle 6, (21) (2007).
Kristin Tracy & Kay F. Macleod: Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy 3, (6) (2007).
Dirlam A. & KF Macleod :The Retinoblastoma tumour suppressor. The Cancer Handbook. 2nd Edition. Chapter 24. Edited by Malcolm R Alison. John Wiley & Sons Ltd. (2006).
Liu H, Thompson AM & KF Macleod: A novel form of pRb expressed during normal myelopoiesis and in tumor associated macrophages. Cell Proliferation 38: 13-24 (2005).
Spike, BT & KF Macleod The Rb tumor suppressor in stress responses and hematopoietic homeostasis. Cell Cycle 4: e181-184 (2005).
Liu, H., Dibling, B., Spike B, Dirlam, A & Macleod, K: Novel functions of the RB tumor suppressor. Curr. Op. Gen. & Dev. 14, 55-64 (2004).
Spike, BT, Dirlam, A, Dibling, BC, Marvin, J, Williams, BO, Jacks, T & KF Macleod The Rb tumor suppressor is required for stress erythropoiesis. The EMBO Journal. 23: 4319-29 (2004).