
Assistant Professor
Ben May Department for Cancer Research
Committee on Cancer Biology
Committee on Cell Physiology
Committee on Molecular Medicine
B.Sc. University of Guelph, Canada
Ph.D. University of Alberta, Canada
CIS W432
Voice: 773/702-6852
Lab: 773/290-8120
Fax: 773/ 702-4476
Lab Website:
nashlab.bsd.uchicago.edu
Piers D. Nash, Ph.D.
Research / References / Lab Website
Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., and Nash, P.D. (2006) The Human and Mouse Complement of SH2 Domain Proteins – establishing the boundaries of phosphotyrosine signaling. Molecular Cell 22: 851-868.
Leong, H., Sloan, J.R., Nash, P.D. and Greene, G.L. (2005) Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. Molecular Endocrinology 19(12): 2930-42.
Pawson, T. & Nash, P. (2003) Assembly of cell regulatory systems through protein interaction domains. Science 300: 445-452.
Bladt, F., Aippersbach, E., Gelkop, S., Strasser, G. A., Nash, P., Tafuri, A., Gertler, F., Pawson, T. (2003) The murine Nck SH2/SH3 adaptors regulate mesoderm-derived embryonic structures in vivo and the cellular actin network. Molecular and Cellular Biology 23 (13): 4586-4597.
Pawson, T., and Nash, P. (2003) Modular protein interaction domains in cellular communication. Handbook of Cell Signaling. Volume 1. Chapter 67, pages 379-385.
Tong, J., Elowe, S., Nash, P., Pawson, T. (2003) Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAP kinase signaling and biological activity. Journal of Biological Chemistry 278: 6111-6119.
Nash, P., Berry, D., Liu, S., Pawon, T., McGlade, J. (2002). A high affinity Arg-X-X-Lys SH3-binding motif confers specificity for the interaction between Gads and SLP-76 in T-cell signaling. Current Biology 12: 1336-1341.
Pawson, T., Raina, M., Nash, P. (2002). Interaction domains: From simple binding events to complex cellular behaviour. FEBS Letters 513: 2-10.
Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F.B., Mendenhall, M.D., Sicheri, F., Pawson, T., Tyers, M. (2001) Multi-site phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414: 514-521.
This article was the focus of the following reviews and comments:
• Ferrell, J. E. Jr. (2001) Six steps to destruction Nature 414: 498-499.
• Deshaies, R.J. and Ferrell, J. E. Jr. (2002) Multisite Phosphorylation and the Countdown to S Phase. Cell 107: 819-822,
• Harper, J. W. (2002) A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends in Cell Biology 12(3): 104-107.
• Tromans, A. (2001) Highlights of the Week: Switching on S-Phase. Nature Reviews Molecular Cell Biology 2:873.
Pawson, T., Gish, G., Nash, P. (2001). SH2 domains, interaction modules and cellular wiring. Trends in Cell Biology 11(12): 504-511.
Pawson, T. and Nash, P. (2000) Protein-protein interactions define specificity in signal transduction. Genes & Development 14 (9): 1027–1047.
Nash, P., McFadden, G. and Whitty, A. (2000) The application of linear free energy relationships to SERPIN mechanism. FEBS Letters 475: 1-6.
Nash, P., Barry, M., Seet, B., Jahns, K., Hota, S., Heger, J., Hodgkinson, C., Graham, K., Jackson, R., McFadden, G. (2000) Post-translational modification of the myxoma virus anti-inflammatory serpin, SERP-1. Biochemcal Journal 347: 375-382.
Nash, P., Barrett, J., Cao, J., Hota-Mitchell, S., Lalani, A., Everett, H., Xu, X., Robichaud, J., Hnatiuk, S., Ainslie, C., Seet, B., and McFadden, G. (1999) Poxvirus immunomodulatory proteins are a window to the immune system: the myxoma virus story. Immunological Reviews 168: 103-120.
Nash, P., Whitty, A., Handwerker, J., Macen, J., and McFadden, G. (1998) Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1. Journal of Biological Chemistry 273 (33): 20982-20991.
Nash, P., Lucas, A., and McFadden, G. SERP-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection. "The SERPINS", Plenum Press, New York. Chapter 19: 195-205 (1997).
