Piers D. Nash, Ph.D.
Appointments:

Assistant Professor
Ben May Department for Cancer Research

Committee on Cancer Biology

Committee on Cell Physiology

Committee on Molecular Medicine

Education:

B.Sc. University of Guelph, Canada

Ph.D. University of Alberta, Canada

 

Contact:

CIS W432

Voice: 773/702-6852
Lab: 773/290-8120
Fax: 773/ 702-4476


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Lab Website:
nashlab.bsd.uchicago.edu

Piers D. Nash, Ph.D.
Research / References / Lab Website


Liu, B.A., Jablonowski, K., Raina, M., Arcé, M., Pawson, T., and Nash, P.D. (2006) The Human and Mouse Complement of SH2 Domain Proteins – establishing the boundaries of phosphotyrosine signaling. Molecular Cell 22: 851-868.

Leong, H., Sloan, J.R., Nash, P.D. and Greene, G.L. (2005) Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. Molecular Endocrinology 19(12): 2930-42.

Pawson, T. & Nash, P. (2003) Assembly of cell regulatory systems through protein interaction domains. Science 300: 445-452.

Bladt, F., Aippersbach, E., Gelkop, S., Strasser, G. A., Nash, P., Tafuri, A., Gertler, F., Pawson, T. (2003) The murine Nck SH2/SH3 adaptors regulate mesoderm-derived embryonic structures in vivo and the cellular actin network. Molecular and Cellular Biology 23 (13): 4586-4597.

Pawson, T., and Nash, P. (2003) Modular protein interaction domains in cellular communication. Handbook of Cell Signaling. Volume 1. Chapter 67, pages 379-385.

Tong, J., Elowe, S., Nash, P., Pawson, T. (2003) Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAP kinase signaling and biological activity. Journal of Biological Chemistry 278: 6111-6119.

Nash, P., Berry, D., Liu, S., Pawon, T., McGlade, J. (2002). A high affinity Arg-X-X-Lys SH3-binding motif confers specificity for the interaction between Gads and SLP-76 in T-cell signaling. Current Biology 12: 1336-1341.

Pawson, T., Raina, M., Nash, P. (2002). Interaction domains: From simple binding events to complex cellular behaviour. FEBS Letters 513: 2-10.

Nash, P., Tang, X., Orlicky, S., Chen, Q., Gertler, F.B., Mendenhall, M.D., Sicheri, F., Pawson, T., Tyers, M. (2001) Multi-site phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 414: 514-521.
This article was the focus of the following reviews and comments:
• Ferrell, J. E. Jr. (2001) Six steps to destruction Nature 414: 498-499.
• Deshaies, R.J. and Ferrell, J. E. Jr. (2002) Multisite Phosphorylation and the Countdown to S Phase. Cell 107: 819-822,
• Harper, J. W. (2002) A phosphorylation-driven ubiquitination switch for cell-cycle control. Trends in Cell Biology 12(3): 104-107.
• Tromans, A. (2001) Highlights of the Week: Switching on S-Phase. Nature Reviews Molecular Cell Biology 2:873.

Pawson, T., Gish, G., Nash, P. (2001). SH2 domains, interaction modules and cellular wiring. Trends in Cell Biology 11(12): 504-511.

Pawson, T. and Nash, P. (2000) Protein-protein interactions define specificity in signal transduction. Genes & Development 14 (9): 1027–1047.

Nash, P., McFadden, G. and Whitty, A. (2000) The application of linear free energy relationships to SERPIN mechanism. FEBS Letters 475: 1-6.

Nash, P., Barry, M., Seet, B., Jahns, K., Hota, S., Heger, J., Hodgkinson, C., Graham, K., Jackson, R., McFadden, G. (2000) Post-translational modification of the myxoma virus anti-inflammatory serpin, SERP-1. Biochemcal Journal 347: 375-382.

Nash, P., Barrett, J., Cao, J., Hota-Mitchell, S., Lalani, A., Everett, H., Xu, X., Robichaud, J., Hnatiuk, S., Ainslie, C., Seet, B., and McFadden, G. (1999) Poxvirus immunomodulatory proteins are a window to the immune system: the myxoma virus story. Immunological Reviews 168: 103-120.

Nash, P., Whitty, A., Handwerker, J., Macen, J., and McFadden, G. (1998) Inhibitory specificity of the anti-inflammatory myxoma virus serpin, SERP-1. Journal of Biological Chemistry 273 (33): 20982-20991.

Nash, P., Lucas, A., and McFadden, G. SERP-1, A Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection. "The SERPINS", Plenum Press, New York. Chapter 19: 195-205 (1997).