
Professor,
Ben May Department for Cancer Research
Committee on Immunology
Committee on Cancer Biology
The Cancer Center
Diploma, University of Bayreuth, Germany, 1986
Ph.D., University of Bayreuth
Germany, 1988
Habilitation, University of Heidelberg
Germany, 1997
Knapp Room R112
Voice: 773/ 702.4728
Fax: 773/ 702.3701
Marcus E. Peter, Ph.D.
Research / References
Lee, K.-H., Feig, C., Tchikov, V., Schickel, R., Hallas, C., Schuetze, S., Peter, M.E.* and Chan, A.C.* (2006) The role of receptor internalization in CD95 signaling. EMBO J., 25, 1009-1023. * shared senior authorship.
Highlighted in Nature Immunol. 7, 373 (2006) as "CD95 internalization".
Park, S.M., Schickel, R. and Peter, M.E. (2005) Nonapoptotic functions of death receptors and their signaling components. Curr. Opin. Cell Biol., 17, 610-616.
Alappat, E.C., Feig, C., Boyerinas, B., Volkland, J., Samuels, M., Murmann, A.E., Thorburn, A., Kidd, V.J., Slaughter, C.A., Osborn, S., Winoto, A., Tang, W.-J. and Peter, M.E. (2005) Phosphorylation of FADD at serine 194 by CKIa regulates its nonapoptotic activities. Mol. Cell, 19, 321-332.
Peter, M.E., Legembre, P., Barnhart, B.C. (2005) Does CD95 have tumor promoting activities? BBA - Reviews on Cancer, 1755, 25-36.
Vijayan, S., Zhou, P., Rajapaksha, T.W., Alegre, M.L. and Peter, M.E. (2005) Transplanted islets from lpr mice are resistant to autoimmune destruction in a model of streptozotocin-induced type I diabetes. Apoptosis, 10, 725-730.
Legembre, P., Barnhart, B.C., Zheng, L., Vijayan, S., Straus, S.E., Puck, J., Dale, J.K., Lenardo, M. and Peter, M.E. (2004) Induction of apoptosis and activation of NF-kB by CD95 require different signaling thresholds. EMBO Reports, 5, 1084-1089.
Barnhart, B.C., Legembre, P., Pietras, E., Bubici, C., Franzoso, G. and Peter, M.E. (2004) CD95 ligand induces motility and invasiveness of apoptosis resistant tumor cells. EMBO J., 23, 3175-3185.
Press release by Nature Publishing Group on July 22, 2004, "Clue to Cancer spread." Article in New Scientist, July 21, 2004, Vol. 183, 2458, "Renegade gene can aid and abet spread of cancer."
Barnhart, B.C. and Peter, M.E. (2003) The TNF receptor 1: a split personality complex. Cell, 114, 148-150.
Lee, J.C. and Peter, M.E. (2003) Regulation of apoptosis by ubiquitination. Immunol. Rev., 193, 39-47.
Barnhart B.C., Alappat, E., and Peter, M.E. (2003) CD95 Type I and Type II cells. Sem. Immunol., 15, 185-193.
Algeciras-Schimnich, A., Pietras, E., Barnhart, B.C., Legembre, P., Vijayan, S., Holbeck, S.L. and Peter, M.E. (2003) Two CD95 tumor classes with different sensitivites to antitumor drugs. Proc. Natl. Acad. Sci. USA, 100, 11445-11450.
Algeciras-Schimnich, A., Barnhart, B.C. and Peter, M.E. (2002) Apoptosis-independent functions of killer caspases. Curr. Opin. Cell Biol., 14, 721-726.1.
Barnhart, B.C. and Peter, M.E. (2002) Two faces of caspase-8. Nature Immunol., 3: 896-898.
Lee, J.C., Schickling, O., Stegh, A.H., Oshima, R., Dingsdale, D., Cohen, G.M. and Peter, M.E. (2002) DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol., 158, 1051-1066.
Highlighted in the same issue of JCB: "DEDD spells death to caspase substrates."
Algeciras-Schimnich, A., Shen, L., Barnhart, B.C., Murmann, A.E., Burkhardt, J and Peter, M.E. (2002) Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol., 22, 207-220.
Stegh, AH., Herrmann, H., Lampel, S., Weisenberger, D., Andrä, K., Seper, M., Wiche, G., Krammer, P.H. and Peter, M.E. (2000) Identification of the cytolinker plectin as a major early in vivo substrate for caspase-8 during CD95 and TNF-receptor mediated apoptosis. Mol. Cell. Biol., 20, 5665-5679.
Scaffidi, C., Kirchhoff, S., Krammer, P.H. and Peter, M.E. (1999) Apoptosis signaling in lymphocytes. Curr. Opin. Immunol., 11, 277-285.
Peter, M.E. and Krammer, P.H. (1998) Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis. Curr. Opin. Immunol., 10, 545-551.
Stegh, A.H., Schickling, O., Ehret, A., Scaffidi, C., Peterhänsel, C., Längst, G., Hoffmann, T., Grummt, I., Krammer, P.H. and Peter, M.E. (1998) DEDD, a novel death effector containing apoptosis-inducing protein targeted to nucleoli. EMBO J., 17, 5974-5986.
Scaffidi, C., Fulda, S., Srinivasan, A., Li, Feng, Friesen, C., Tomasseli, K.J., Debatin, K.-M., Krammer, P.H. and Peter, M.E. (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J., 17, 1675-1687.
Highlighted in the Scientist as one of the hot papers of 1998: "Deconstructing Tumor Necrosis Factor." (2000) The Scientist, 14:19.
Thome, M., Schneider, P., Hofmann, K., Burns, K., Mattmann, C., Bodmer, J.-L., Schröter, M., Neipel, F., Scaffidi, C., Krammer, P.H., Peter, M.E. and Tschopp, J. (1997) Viral FLICE-inhibitory proteins (FLIPS) prevent apoptosis induced by death receptors. Nature, 386, 517-521.
Medema, J.P., Scaffidi, C., Kischkel, F.C., Shevchenko, A., Mann, M., Krammer, P.H. and Peter, M.E. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16, 2794-2804.
Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O' Rourke, K., Shevchenko, A., Scaffidi, C., Zhang, M., Ni, J., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E.* and Dixit, V.M.* (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex (DISC). Cell, 85, 817-827. * Authors share senior authorship.
Voted by Science to be one of the top 10 discoveries of 1996. 3rd most cited paper in 1997.
Kischkel, F.C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P.H. and Peter, M.E. (1995) Cytotoxicity-dependent APO-1(Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor. EMBO J., 14, 5579-5588.
Minireview in Cell: Ihle and Cleveland. (1995) Contenders in FasL/TNF signaling. Cell, 81:479.
