Im, H., Manolopoulou, M., Malito, E., Shen, Y., Zhao, J., Neant-Fery, M., Sun, C.-Y., Meredith, S.C., Sisodia, S.S., Leissring, M., and Tang, W.-J. (2007) Structure of substrate-free human insulin degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. J. Biol. Chem. 282(35):25453-63.

Johnson, E.C.B., Malito, E., Shen, Y., Pentelute, B., Rich, R., Florián, J., Tang, W.-J., Kent, S.B.H. (2007) New insights from atomic-resolution structures of chemically synthesized HIV-1 protease in complex with inhibitors. J. Mol. Biol. 373(3):573-86.

Johnson, E.C.B. Malito, E., Shen, Y., Rich, D., Tang, W.-J. and Kent, S.B.H. (2007) A biomimetic total chemical synthesis of the HIV-1 protease. J. Am. Chem. Soc. 129(37):11480-11490.

Warren, J., Guo, Q., and Tang, W.-J. (2007) Structure of zinc-bound N-terminal domain of calmodulin reveals the molecular basis for the initial metal-ligated conformation of calmodulin. J. Mol. Biol. 374(2):517-27.

Shen, Y., Joachimiak, A., Rosner, M.R., and Tang, W.-J. (2006) Structures of human insulin degrading enzyme reveal a new substrate recognition mechanism. Nature 443:870-874.

Guo, Q., Shen, Y., Lee, Y.-S., Gibbs, C.S., Mrksich, M., and Tang, W.-J. (2005) Structural basis for the interaction of adenylyl cyclase toxin of Bordetella pertussis with calmodulin. EMBO J, 24:3190-3201.

Shen, Y., Zhukovskaya, N.L., Guo, Q., Florián, J., and Tang, W.-J. (2005) Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. EMBO J. 24:929-941.

Beeler, J.A., Yan, S.-Z., Bykov, S., Murza, A., Asher, S., Tang, W.-J. (2004) A stable C1b soluble protein and its regulation of soluble type 7 adenylyl cyclase: a prototype for soluble C1b model. Biochemistry 43(49):15463-15471.

Lee, Y.-S., Bergson, P., He, W.-S., Mrksich, M., and Tang, W.-J., (2004) Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin. Chem. & Biol. 11:1139-1146.

Guo, Q., Shen, Y.-Q., Zhukovskaya, N.L., Florian, J., and Tang, W.-J. (2004) Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products, cAMP and pyrophosphate. J. Biol. Chem. 279:29427-29435.

Shen, Y.-Q., Zhukovskaya, N.L., Zimmer, M.I., Soelaiman, S., Wang, C.R., Gibbs, C.S., Tang, W.-J.(2004)Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc. Natl. Acad. Sci. U.S.A. 101:3242-3247.

Soelaiman, S., Wei, B., Bergson, P., Lee, Y.-S., Shen, Y., Mrksich, M., Shoichet, B., Tang, W.-J. (2003) Structure-based inhibitor discovery against anthrax adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough. J. Biol. Chem., 278:25990-25997.

Shen, Y.-Q., Lee, Y.-S., Soelaiman, S., Bergson, P., Lu, D., Chen, A., Beckingham, K., Grabarek, Z., Mrksich, M., Tang, W.-J. (2002) Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins. EMBO J. 21: 6721-6732.

Drum, C.L., Yan, S.-Z., Bard, J., Shen, Y.-Q., Lu, D., Soelaiman, S., Grabarek, Z., Bohm, A., and Tang, W.-J. (2002) Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin. Nature 415:396-402.

Yan, S.-Z. Beeler, J. Chen, Y., Shelton, R.K., and Tang, W.-J. (2001) The regulation of human type 7 adenylyl cyclase by C1b and E. coli peptidyl prolyl isomerase, slyD. J. Biol. Chem. 276: 8500-8506.

Drum, C.L., Yan, S.-Z., Sarac, R., Mabuchi, Y., Beckingham, K., Bohm, A., Grabarek, Z., and Tang, W.-J. (2000) An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis. J. Biol. Chem. 275:36334-36340.