News and Events BMDCR
Huggins Lecture Series
Saturdays, January 13 through March 3, 2007
|
 |
When a patient has any one of a number of infections, their physician may write a prescription for an antibiotic, such as: "Tetracycline, 250 mg. #16. Sig. 1 caps, q.i.d." A dose of 250 mg four times a day for approximately four days is standard for all adolescents and adults, whether prescribed to a 100-lb. young girl or a 300-lb. elderly man. In contrast, when we buy shoes, we buy shoes that fit us. Have you ever wondered why taking medicine is still “one size fits all”?
In the past decade, the rapid advances in molecular biology and information technology, as well as progress in sequencing the human genome offers scientist resources and tools to advance medicine in both its scientific and clinical domains. Personalized medicine is becoming a reality.
These lectures will focus on scientific progress in the area of personalized medicine particularly in the area of chemotherapeutics. Chemotherapeutics tend to be more toxic thus, a tailored approach will greatly improve the quality of life for patients susceptible to adverse events associated with these medications. The first lecture will be an overview of pharmacogenetics followed by a lecture focused specifically on the mechanism of action and toxicities associated with cancer chemotherapeutic agents. Following lectures will focus on recent successes of the molecularly targeted approach to cancer, such as Gleevec and Her2neu and how pharmacogenomics is used to identify patients at risk for adverse toxicities. A lecture will focus on how the Human Genome Project transformed the field of pharmacology to pharmacogenomics. The final lectures will focus on the future prospects of personalized medicine and discuss a pharmacogenomics bill that Senator Barack Obama drafted for consideration to the US Senate.
These lectures will be addressed to a general audience interested in how modern science is being used to better understand how to tailor therapy for cancer patients. The lectures will provide an overview the field of pharmacogenomics and current approaches and limitations to achieve personalized medicine.
Overview of personalized medicine and cancer treatment |
January 13, 2007 |
View Power Point 
View Adobe PDF
View Flash PaperPharmacology of cancer treatment
|
January 20, 2007 |
Molecularly targeted approach to cancer treatment
|
January 27, 2007 |
Success in applying genetics and genomics in optimize treatment
|
February 3, 2007 |
Human Genome Project and its relationship to pharmacology |
February 10, 2007 |
A great set of cell line tools— Family pedigrees, International HapMap cell lines and NCI60 cell lines |
February 17, 2007 |
Ethical issue in personalized treatment |
February 24, 2007 |
Future Medicines for Cancer |
March 3, 2007 |