Professor of Medicine; Section of Hematology / Oncology
Director, The University of Chicago Cancer Research Center
Director, Cancer Cytogenetics Laboratory
Ben May Department for Cancer Research
BS, Purdue University Genetics
MS, University of Illinois Pathology
PhD, University of Illinois Pathology
Fellowship, The University of Chicago Hematology/Oncology
Contact:
Michelle Le Beau, Ph.D.
Research / References
Research
Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of a myeloid leukemia-related gene involved in the –5/del(5q) characteristic of therapy-related acute myeloid leukemia; genetic characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing and elucidation of the mechanism for the genetic instability characteristic of chromosomal fragile sites.